Gene name:
Fto (Kiaa1752) ;
Protein name:
Alpha-ketoglutarate-dependent dioxygenase FTO ;
Alternative:
Protein fatso ;Fat mass and obesity-associated protein ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Monomer. May also exist as homodimer.
Function:
Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Has no activity towards 1-methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. Contributes to the regulation of body size and body fat accumulation.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MKRVQTAEER | EREAKKLRLL | EELEDTWLPY | LTPKDDEFYQ | QWQLKYPKLV |
100:
FREAGSIPEE | LHKEVPEAFL | TLHKHGCLFR | DVVRIQGKDV | LTPVSRILIG |
150:
DPGCTYKYLN | TRLFTVPWPV | KGCTVKYTEA | EIAAACQTFL | KLNDYLQVET |
200:
IQALEELAVR | EKANEDAVPL | CMAEFPRAGV | GPSCDDEVDL | KSRAAYNVTL |
250:
LNFMDPQKMP | YLKEEPYFGM | GKMAVSWHHD | ENLVDRSAVA | VYSYSCEGSE |
300:
DESEDESSFE | GRDPDTWHVG | FKISWDIETP | GLTIPLHQGD | CYFMLDDLNA |
350:
THQHCVLAGS | QPRFSSTHRV | AECSTGTLDY | ILERCQLALQ | NVLNDSDDGD |
400:
VSLKSFDPAV | LKQGEEIHNE | VEFEWLRQFW | FQGNRYKLCT | DWWCEPMTHL |
450:
EGLWKKMESM | TNAVLREVKR | EGLPVEQRSE | ILSAILVPLT | VRQNLRKEWH |
500:
ARCQSRVVRT | LPVQQKPDCR | PYWEKDDPSM | PLPFDLTDVV | SELRGQLLEA |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
ELISA Kit for Mouse Alpha-ketoglutarate-dependent dioxygenase FTO
ELISA Kit for Mouse Alpha-ketoglutarate-dependent dioxygenase FTO
ELISA Kit for Mouse Alpha-ketoglutarate-dependent dioxygenase FTO
CLIA Kit for Mouse Alpha-ketoglutarate-dependent dioxygenase FTO
CLIA Kit for Mouse Alpha-ketoglutarate-dependent dioxygenase FTO
CLIA Kit for Mouse Alpha-ketoglutarate-dependent dioxygenase FTO
Polyclonal Antibody for Mouse Alpha-ketoglutarate-dependent dioxygenase FTO
Polyclonal Antibody for Mouse Alpha-ketoglutarate-dependent dioxygenase FTO
Polyclonal Antibody for Mouse Alpha-ketoglutarate-dependent dioxygenase FTO
Monoclonal Antibody for Mouse Alpha-ketoglutarate-dependent dioxygenase FTO
Monoclonal Antibody for Mouse Alpha-ketoglutarate-dependent dioxygenase FTO
Monoclonal Antibody for Mouse Alpha-ketoglutarate-dependent dioxygenase FTO
Protein for Mouse Alpha-ketoglutarate-dependent dioxygenase FTO
Protein for Mouse Alpha-ketoglutarate-dependent dioxygenase FTO
Protein for Mouse Alpha-ketoglutarate-dependent dioxygenase FTO
R&D Technical Data
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Precision
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Recovery
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Linearity
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1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue :
Brain .
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Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4)
strain :
C57BL/6J .
strain :
NOD .
tissue :
Aorta .
tissue :
Bone .
tissue :
Corpora quadrigemina .
tissue :
Skin .
tissue :
Thymus .
tissue :
Vein .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
strain :
C57BL/6 .
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FVB/N .
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Brain .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DISRUPTION PHENOTYPE;SUBCELLULAR LOCATION;FUNCTION;TISSUE SPECIFICITY
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PubMed ]
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[
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;SUBUNIT;CIRCULAR DICHROISM;MUTAGENESIS OF ILE-367