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Index > Protein center > Fto(Gene name) > Mouse
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  • Fto (Gene name),
  • Alpha-ketoglutarate-dependent dioxygenase FTO (Protein name ),  FTO_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Fto(Kiaa1752);
    Protein name:
    Alpha-ketoglutarate-dependent dioxygenase FTO;
    Alternative:
    Protein fatso;Fat mass and obesity-associated protein;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Monomer. May also exist as homodimer.
    Function:
    Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Has no activity towards 1-methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. Contributes to the regulation of body size and body fat accumulation.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    502
    Sequence:
    50:
    MKRVQTAEER | EREAKKLRLL | EELEDTWLPY | LTPKDDEFYQ | QWQLKYPKLV | 
    100:
    FREAGSIPEE | LHKEVPEAFL | TLHKHGCLFR | DVVRIQGKDV | LTPVSRILIG | 
    150:
    DPGCTYKYLN | TRLFTVPWPV | KGCTVKYTEA | EIAAACQTFL | KLNDYLQVET | 
    200:
    IQALEELAVR | EKANEDAVPL | CMAEFPRAGV | GPSCDDEVDL | KSRAAYNVTL | 
    250:
    LNFMDPQKMP | YLKEEPYFGM | GKMAVSWHHD | ENLVDRSAVA | VYSYSCEGSE | 
    300:
    DESEDESSFE | GRDPDTWHVG | FKISWDIETP | GLTIPLHQGD | CYFMLDDLNA | 
    350:
    THQHCVLAGS | QPRFSSTHRV | AECSTGTLDY | ILERCQLALQ | NVLNDSDDGD | 
    400:
    VSLKSFDPAV | LKQGEEIHNE | VEFEWLRQFW | FQGNRYKLCT | DWWCEPMTHL | 
    450:
    EGLWKKMESM | TNAVLREVKR | EGLPVEQRSE | ILSAILVPLT | VRQNLRKEWH | 
    500:
    ARCQSRVVRT | LPVQQKPDCR | PYWEKDDPSM | PLPFDLTDVV | SELRGQLLEA | 
    502:
    RS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    KEGG:
    String:
    UniGene:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Alpha-ketoglutarate-dependent dioxygenase FTO
    Cat.:
    E4267h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse Alpha-ketoglutarate-dependent dioxygenase FTO
    Cat.:
    E4267r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse Alpha-ketoglutarate-dependent dioxygenase FTO
    Cat.:
    E4267m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Alpha-ketoglutarate-dependent dioxygenase FTO
    Cat.:
    U4267h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse Alpha-ketoglutarate-dependent dioxygenase FTO
    Cat.:
    U4267m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Alpha-ketoglutarate-dependent dioxygenase FTO
    Cat.:
    U4267r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse Alpha-ketoglutarate-dependent dioxygenase FTO
    Cat.:
    P4267Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Alpha-ketoglutarate-dependent dioxygenase FTO
    Cat.:
    P4267Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Alpha-ketoglutarate-dependent dioxygenase FTO
    Cat.:
    P4267Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Alpha-ketoglutarate-dependent dioxygenase FTO
    Monoclonal Antibody for Mouse Alpha-ketoglutarate-dependent dioxygenase FTO
    Monoclonal Antibody for Mouse Alpha-ketoglutarate-dependent dioxygenase FTO
    Protein for Mouse Alpha-ketoglutarate-dependent dioxygenase FTO
    Protein for Mouse Alpha-ketoglutarate-dependent dioxygenase FTO
    Protein for Mouse Alpha-ketoglutarate-dependent dioxygenase FTO

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Cloning of Fatso (Fto), a novel gene deleted by the Fused toes (Ft) mouse mutation."
      Peters T. , Ausmeier K. , Ruether U.
      Mamm. Genome10:983-986(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N. , Kikuno R. , Ohara R. , Inamoto S. , Koseki H. , Hiraoka S. , Saga Y. , Nagase T. , Ohara O. , Koga H.
      DNA Res.10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Brain.
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4)
      strain: C57BL/6J.
      strain: NOD.
      tissue: Aorta.
      tissue: Bone.
      tissue: Corpora quadrigemina.
      tissue: Skin.
      tissue: Thymus.
      tissue: Vein.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      strain: C57BL/6.
      strain: FVB/N.
      tissue: Brain.
      tissue: Kidney.
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;COFACTOR;ENZYME REGULATION;SUBCELLULAR LOCATION;MUTAGENESIS OF HIS-304 AND ARG-313;INDUCTION;TISSUE SPECIFICITY
    6. 6.
      "Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO."
      Jia G. , Yang C.G. , Yang S. , Jian X. , Yi C. , Zhou Z. , He C.
      FEBS Lett.582:3313-3319(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;BIOPHYSICOCHEMICAL PROPERTIES
    7. 7.
      "Inactivation of the Fto gene protects from obesity."
      Fischer J. , Koch L. , Emmerling C. , Vierkotten J. , Peters T. , Bruning J.C. , Ruther U.
      Nature458:894-898(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;SUBCELLULAR LOCATION;FUNCTION;TISSUE SPECIFICITY
    8. 8.
      "A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene."
      Church C. , Lee S. , Bagg E.A. , McTaggart J.S. , Deacon R. , Gerken T. , Lee A. , Moir L. , Mecinovic J. , Quwailid M.M. , Schofield C.J. , Ashcroft F.M. , Cox R.D.
      PLoS Genet.5:E1000599-E1000599(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;SUBUNIT;CIRCULAR DICHROISM;MUTAGENESIS OF ILE-367
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